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HOW WE DETERMINE SCORES Learn more About EWG VERIFIED®

Data: Fair

Cyclopentasiloxane

IMAGE SOURCE: PubChem

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Other Concerns

Enhanced skin absorption, Neurotoxicity (low), Endocrine disruption (low), Persistence and bioaccumulation (high), Non-reproductive organ system toxicity (low_moderate), Ecotoxicology (low), and Contamination concerns (high)

SYNONYMS

● 4-04-00-04128 (BEILSTEIN HANDBOOK REFERENCE)
● CHEMBL1885178
● DSSTOX_RID_78338
● DTXSID1027184
● D5 CYCLOMETHICONE, PHARMACEUTICAL SECONDARY STANDARD; CERTIFIED REFERENCE MATERIAL
● SCHEMBL28497
● KSC493E2H
● CTK3J3223
● DSSTOX_GSID_27184
● ACMC-209LD1

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient

Cyclopentasiloxane (cyclomethicone) is a silicon-based cyclic compound; may be associated with environmental toxicity.

Common concerns

See how this product scores for common concerns.

  • LOW
    Cancer
  • LOW
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reproductive Toxicity
  • LOW
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

Expand content Collapse content
styling gel/lotion66 products
conditioner390 products
hair spray186 products
hair treatment/serum478 products
mask124 products
around-eye cream97 products
facial moisturizer/treatment294 products
anti-aging53 products
shampoo115 products
foundation2607 products
makeup remover51 products
shaving cream (men's)5 products
hair styling aid167 products
hair-loss treatment5 products
skin fading/lightener5 products
CC cream75 products
moisturizer285 products
body oil27 products
antiperspirant/deodorant720 products
antiperspirant/deodorant (men's)308 products
after shave14 products
sunless tanning30 products
concealer1297 products
blush150 products
eye liner559 products
lip liner240 products
BB cream103 products
hair color and bleaching19 products
detangler33 products
baby oil8 products
shaving cream1 products
hand cream81 products
fragrance for women5 products
body spray7 products
diaper cream1 products
bronzer/highlighter135 products
oil controller4 products
makeup primer242 products
nail treatment8 products
eye shadow508 products
lipstick972 products
hair relaxer4 products
body firming lotion44 products
mascara126 products
facial powder23 products
styling mousse/foam17 products
eye makeup remover21 products
foot moisturizer6 products
brow liner183 products
facial cleanser16 products
Under Eye Concealers13 products
serums & essences155 products
beard oil10 products
Dry Shampoo and Hair Powders10 products
Other Hair Care Preparations3 products
Oils & Serums3 products
lip balm21 products
cuticle treatment3 products
body wash/cleanser5 products
toners/astringents7 products
lip gloss73 products
daily use with SPF182 products
Facial Sun Care2 products
recreational sunscreen79 products
setting powder/spray8 products
baby sunscreen12 products
baby lotion4 products
Facial Cleansing Water3 products
lip balm with SPF6 products
bath oil/salts/soak12 products
beard care7 products
fragrance for men1 products
glitter1 products
body art2 products
Eye Shadow Primers4 products
after sun product2 products
tanning oil4 products
exfoliant/scrub9 products
hair removal waxes1 products
other eye makeup11 products
damaged skin treatment1 products
eyelash glue2 products
Preshave Preparations1 products
lip plumper9 products
hand sanitizer1 products
liquid hand soap1 products
foot cleansing1 products
Decollete and Neck Creams1 products
nail polish1 products
Wipes1 products
mouthwash1 products

Contamination concerns

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Chemical
CYCLOTETRASILOXANE

Endocrine disruption

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CONCERN REFERENCE
One or more animal studies show endocrine disruption at moderate dosesInduction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5)(1999-07-01)
One or more animal studies show endocrine disruption at moderate dosesA two-generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation(2007-02-01)

Neurotoxicity

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CONCERN REFERENCE
One or more animal studies show effects at moderate dosesInvestigation of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) as dopamine D2- receptor agonists(2005-01-01)

Cancer

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CONCERN REFERENCE
One or more animal studies show tumor formation at moderate dosesDecamethylcyclopentasiloxane: A 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in Fischer-344 rats(2005-01-01)

Persistence and bioaccumulation

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CONCERN REFERENCE
Persistent, bioaccumulative in wildlife and humansECAH Candidate List of substances of very high concern for Authorisation(2018-06-27)
Persistent, bioaccumulative in wildlifeEnvironment Canada

Informational

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CONCERN REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review (CIR)

Ecotoxicology

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CONCERN REFERENCE
Suspected to be an environmental toxinEnvironment Canada
Suspected to be an environmental toxinEnvironment Canada

Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Classified as expected to be toxic or harmfulEnvironment Canada
  • Induction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5)(1999-07-01)
  • A two-generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation(2007-02-01)
  • Investigation of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) as dopamine D2- receptor agonists(2005-01-01)
  • Decamethylcyclopentasiloxane: A 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in Fischer-344 rats(2005-01-01)
  • ECAH Candidate List of substances of very high concern for Authorisation(2018-06-27)
  • Environment Canada
  • Cosmetic Ingredient Review (CIR)

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.


HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG Verified® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend
WEIGHT-OF-EVIDENCE APPROACH

A product’s hazard score is not an average of the ingredients’ hazard scores. It is calculated using a weight-of-evidence approach that factors in all of the hazards or health impacts associated with the ingredients.

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability
NONE

Ingredients have not been assessed.

LIMITED-FAIR

There is only a modest volume of research.

GOOD-ROBUST

Ingredients have been studied extensively.

Can’t find your product?

Enter the ingredients in EWG’s Build Your Own Report tool to get an approximate score for that product.

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